Proteopedia

4is2

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Crystal structure of the apo form of a 3alpha-hydroxysteroid dehydrogenase (BaiA2) associated with secondary bile acid synthesis from Clostridium scindens VPI12708 at 1.90 A resolutionCrystal structure of the apo form of a 3alpha-hydroxysteroid dehydrogenase (BaiA2) associated with secondary bile acid synthesis from Clostridium scindens VPI12708 at 1.90 A resolution

Structural highlights

4is2 is a 1 chain structure with sequence from Atcc 35704. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
NonStd Res:
Gene:baiA, BAIA2 (ATCC 35704)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BAIA2_EUBSP] 7-alpha-dehydroxylation of cholic acid and chenodeoxycholate, yielding deoxycholic acid and lithocholic acid, respectively. Highest affinity with taurochenodeoxycholic acid.

4is2, resolution 1.90Å

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OCA
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