Akt/PKB signaling pathway

The Akt signaling pathway or PI3K-Akt signaling pathway is a signal transduction pathway that promotes survival and growth in response to extracellular signals. Key proteins involved are PI3K (phosphatidylinositol 3-kinase) and Akt (protein kinase B). Protein kinase B (PKB), also known as Akt, is the collective name of a set of three serine/threonine-specific protein kinases that play key roles in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration. See also Signal transduction. Activation Akt/PKB via Receptor tyrosine kinases/Ras Ras activation GTPase KRas Allosteric modulation of H-Ras GTPase Phosphoinositide 3-Kinases Phosphoinositide 3-Kinases or phosphatidylinositol 3-kinase (PI3K) are a family of ubiquitously distributed lipid kinases, that play a critical role in the regulation of numerous cellular processes including cellular growth and morphology, programmed cell death, cell motility and adhesion, mitogenesis and glucose uptake. The Structure of PI3K Phosphoinositide 3-Kinases PI3K Activation, Inhibition, & Medical Implications Akt/PKB AKT1 RAC(Rho family)-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 (Src homology 2-like) protein domains. See 3mv5. AKT2 AKT2, also known as RAC-beta serine/threonine-protein kinase, is an enzyme that in humans is encoded by the AKT2 gene. It influences metabolite storage as part of the insulin signal transduction pathway. See 3d0e.

spinqualitylabelsall models PI3K (grey) complex with NISH2 P85α and wortmannin (PDB code 3hhm) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image