2ypd

Crystal structure of the Jumonji domain of human Jumonji domain containing 1C proteinCrystal structure of the Jumonji domain of human Jumonji domain containing 1C protein

Structural highlights

2ypd is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	2ypr
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[JHD2C_HUMAN] Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).

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OCA