3fb6

KcsA Potassium channel in the partially open state with 16 A opening at T112KcsA Potassium channel in the partially open state with 16 A opening at T112

Structural highlights

3fb6 is a 3 chain structure with sequence from "actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965 and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	3f5w, 3f7v, 3f7y, 3fb5, 3fb7, 3fb8
Gene:	kcsA, skc1 ("Actinomyces lividans" Krasil'nikov et al. 1965)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Schrempf H, Schmidt O, Kummerlen R, Hinnah S, Muller D, Betzler M, Steinkamp T, Wagner R. A prokaryotic potassium ion channel with two predicted transmembrane segments from Streptomyces lividans. EMBO J. 1995 Nov 1;14(21):5170-8. PMID:7489706

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OCA

[1] Schrempf H, Schmidt O, Kummerlen R, Hinnah S, Muller D, Betzler M, Steinkamp T, Wagner R. A prokaryotic potassium ion channel with two predicted transmembrane segments from Streptomyces lividans. EMBO J. 1995 Nov 1;14(21):5170-8. PMID:7489706

[1]

3fb6

KcsA Potassium channel in the partially open state with 16 A opening at T112KcsA Potassium channel in the partially open state with 16 A opening at T112

Structural highlights

Function

Evolutionary Conservation

See Also

References

Contents

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3fb6

KcsA Potassium channel in the partially open state with 16 A opening at T112KcsA Potassium channel in the partially open state with 16 A opening at T112

Structural highlights

Function

Evolutionary Conservation

See Also

References

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