2pa1

Structure of the PDZ domain of human PDLIM2 bound to a C-terminal extension from human beta-tropomyosinStructure of the PDZ domain of human PDLIM2 bound to a C-terminal extension from human beta-tropomyosin

Structural highlights

2pa1 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:	PDLIM2, PP6345 (HUMAN)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PDLI2_HUMAN] Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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OCA