6irc

C-terminal domain of Drosophila phospholipase b NORPA, methylatedC-terminal domain of Drosophila phospholipase b NORPA, methylated

Structural highlights

6irc is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:
Activity:	Phosphoinositide phospholipase C, with EC number 3.1.4.11
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PIPA_DROME] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway (PubMed:2457447). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).[UniProtKB:Q9P212]^[1] ^[2]

References

↑ Bloomquist BT, Shortridge RD, Schneuwly S, Perdew M, Montell C, Steller H, Rubin G, Pak WL. Isolation of a putative phospholipase C gene of Drosophila, norpA, and its role in phototransduction. Cell. 1988 Aug 26;54(5):723-33. PMID:2457447
↑ Lee KA, Kim B, Bhin J, Kim DH, You H, Kim EK, Kim SH, Ryu JH, Hwang D, Lee WJ. Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes. Cell Host Microbe. 2015 Feb 11;17(2):191-204. doi: 10.1016/j.chom.2014.12.012., Epub 2015 Jan 29. PMID:25639794 doi:http://dx.doi.org/10.1016/j.chom.2014.12.012

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OCA

[1] Bloomquist BT, Shortridge RD, Schneuwly S, Perdew M, Montell C, Steller H, Rubin G, Pak WL. Isolation of a putative phospholipase C gene of Drosophila, norpA, and its role in phototransduction. Cell. 1988 Aug 26;54(5):723-33. PMID:2457447

[2] Lee KA, Kim B, Bhin J, Kim DH, You H, Kim EK, Kim SH, Ryu JH, Hwang D, Lee WJ. Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes. Cell Host Microbe. 2015 Feb 11;17(2):191-204. doi: 10.1016/j.chom.2014.12.012., Epub 2015 Jan 29. PMID:25639794 doi:http://dx.doi.org/10.1016/j.chom.2014.12.012

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