by Eric Martz
SARS-CoV-2 spike protein undergoes a dramatic conformational rearrangement that plays a central role in fusing the coronavirus membrane with the host cell membrane. Similar conformational transformations have been observed for the spike protein of SARS-CoV and mouse hepatitis virus, among others. These rearrangements also have much in common with the membrane fusion mechansism of influenza hemagglutinin.
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