General secretion pathway protein

Function General secretion pathway proteins (Eps) are used by gram-negative pathogenic bacteria to transport their virulence factors outside of the cell via type II secretion system or T2SS. Examples are the transport of cholera toxin by Vibrio cholerae and exotoxin A by Pseudomonas aeruginosa. In Pseudomonas aeruginosa the Eps are named Xcp. EpsG,H,I,J,K are named PulG, PulH, PulI, PulJ, PulK. See Pseudopilin. Structural highlights The 3D structure of the bacterial core shows a 15-fold rotationally symmetric PulD called secretin which inserts into the cell membrane and enables conductance of substrate intothe external environment.

spinqualitylabelsall models PulC + PulD + PulS complex (PDB code 6hcg) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of general secretion pathway protein3D structures of general secretion pathway protein

Updated on 01-May-2020

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• General secretion pathway protein AB
  • 4g54 - VvEpsD residues 326-584 - Vibrio vulnificus
    
• General secretion pathway protein B
  • 4wfw - DdEpsB residues 112-201 - Dickeya dadantii
    
• General secretion pathway protein C
  • 2i4s, 2i6v - VcEpsC PDZ domain 204-305 - Vibrio cholerae
    
  • 2lnv - DdEpsC residues 77-172
    
• General secretion pathway protein C+D+S
  • 6hcg - KpEpsC + EpsD + EpsS - Klebsiella pneumoniae - Cryo EM
    
• General secretion pathway protein D
  • 6i1y - VvEpsD residues 121-673 - Cryo EM
    
  • 3ezj - EpsD N-terminal 40-277 + nanobody - Eschericia coli
    
  • 4e9j - PaEpsD N-terminal 35-277 - Pseudomonas aeruginosa
    
  • 4ec5 - PaEpsD N-terminal (mutant)
    
  • 5wln - PaEpsD residues 35-658 - Cryo EM
    
  • 6i1x - EpsD residues 122-645 - Aeromonas hydrophila - Cryo EM
    
• General secretion pathway protein E
  • 1p9w, 1p9r - VcEpsE residues 1-90
    
  • 4ksr, 4kss - VcEpsE residues 100-503
    
• General secretion pathway protein E+L
  • 2bh1 - VcEpsE residues 1-96 + VcEpsL residues 5-246
    
• General secretion pathway protein F
  • 5nbg - DdEpsF residues 65-172
    
  • 2vma, 2vmb, 3c1q - VcEpsF residues 56-170
    
• General secretion pathway protein L
  • 1yf5, 1w97 - VcEpsL cytoplasmic domain 1-248
    
  • 2w7v - EpsL periplasmic domain 319-404 - Vibrio parahaemolyticus
    
  • 5n7l - PaEpsL periplasmic domain 303-382
    
  • 5hl8 - KpEpsL C-terminal domain 309-397
    
• General secretion pathway protein M
  • 1uv7 - VcEpsM periplasmic domain 65-165
    
• General secretion pathway protein G,H,I,J,K see Pseudopilin