Cytoglobin

Function

Cytoglobin (CYGB) is a globin which is ubiquitously expressed invertebrate tissues. CYGB is located in both cytoplasm and nucleus may provide O₂ for enzymatic reactions and may be involved in NO-signaling pathways^[1].

Disease

Loss of CYGB accelerates liver fibrosis and cancer development^[2].

Structural highlights

^[3]. . Water molecules are shown as red spheres.

Human cytoglobin including the heme group complex with CO (PDB code 3ag0)

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3D structures of cytoglobin3D structures of cytoglobin

Updated on 20-February-2019

2dc3, 1v5h – hCYGB - human
1umo – hCYGB (mutant)
3ag0 – hCYGB + CO
1urv, 1ury, 1ut0, 1ux9 – hCYGB (mutant) + Fe(CN)6
4b3w – hCYGB (mutant) + CN + Fe(CN)6

ReferencesReferences

↑ Ascenzi P, Bocedi A, de Sanctis D, Pesce A, Bolognesi M, Marden MC, Dewilde S, Moens L, Hankeln T, Burmester T. Neuroglobin and cytoglobin: Two new entries in the hemoglobin superfamily*. Biochem Mol Biol Educ. 2004 Sep;32(5):305-13. doi: 10.1002/bmb.2004.494032050386. PMID:21706744 doi:http://dx.doi.org/10.1002/bmb.2004.494032050386
↑ Thuy Le TT, Hai NT, Hai H, Kawada N. Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases. Histol Histopathol. 2016 Mar;31(3):257-67. doi: 10.14670/HH-11-694. Epub 2015 Nov, 11. PMID:26554615 doi:http://dx.doi.org/10.14670/HH-11-694
↑ Makino M, Sawai H, Shiro Y, Sugimoto H. Crystal structure of the carbon monoxide complex of human cytoglobin. Proteins. 2010 Nov 30. doi: 10.1002/prot.22950. PMID:21254233 doi:10.1002/prot.22950

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Dana M. Grass

[1] Ascenzi P, Bocedi A, de Sanctis D, Pesce A, Bolognesi M, Marden MC, Dewilde S, Moens L, Hankeln T, Burmester T. Neuroglobin and cytoglobin: Two new entries in the hemoglobin superfamily*. Biochem Mol Biol Educ. 2004 Sep;32(5):305-13. doi: 10.1002/bmb.2004.494032050386. PMID:21706744 doi:http://dx.doi.org/10.1002/bmb.2004.494032050386

[2] Thuy Le TT, Hai NT, Hai H, Kawada N. Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases. Histol Histopathol. 2016 Mar;31(3):257-67. doi: 10.14670/HH-11-694. Epub 2015 Nov, 11. PMID:26554615 doi:http://dx.doi.org/10.14670/HH-11-694

[3] Makino M, Sawai H, Shiro Y, Sugimoto H. Crystal structure of the carbon monoxide complex of human cytoglobin. Proteins. 2010 Nov 30. doi: 10.1002/prot.22950. PMID:21254233 doi:10.1002/prot.22950

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