6keq

Crystal structure of D113A mutant of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14 (DmGSTE14), in apo-formCrystal structure of D113A mutant of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14 (DmGSTE14), in apo-form

Structural highlights

6keq is a 2 chain structure with sequence from Drome. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	GstE14, GSTD14-14, nobo, CG4688 (DROME)
Activity:	Glutathione transferase, with EC number 2.5.1.18
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[GSTEE_DROME] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). Essential for ecdysteroid biosynthesis (PubMed:25344753, PubMed:25300303). May be involved in detoxification (PubMed:22082028).^[1] ^[2] ^[3]

References

↑ Saisawang C, Wongsantichon J, Ketterman AJ. A preliminary characterization of the cytosolic glutathione transferase proteome from Drosophila melanogaster. Biochem J. 2012 Feb 15;442(1):181-90. doi: 10.1042/BJ20111747. PMID:22082028 doi:http://dx.doi.org/10.1042/BJ20111747
↑ Enya S, Ameku T, Igarashi F, Iga M, Kataoka H, Shinoda T, Niwa R. A Halloween gene noppera-bo encodes a glutathione S-transferase essential for ecdysteroid biosynthesis via regulating the behaviour of cholesterol in Drosophila. Sci Rep. 2014 Oct 10;4:6586. doi: 10.1038/srep06586. PMID:25300303 doi:http://dx.doi.org/10.1038/srep06586
↑ Chanut-Delalande H, Hashimoto Y, Pelissier-Monier A, Spokony R, Dib A, Kondo T, Bohere J, Niimi K, Latapie Y, Inagaki S, Dubois L, Valenti P, Polesello C, Kobayashi S, Moussian B, White KP, Plaza S, Kageyama Y, Payre F. Pri peptides are mediators of ecdysone for the temporal control of development. Nat Cell Biol. 2014 Nov;16(11):1035-44. doi: 10.1038/ncb3052. Epub 2014 Oct 26. PMID:25344753 doi:http://dx.doi.org/10.1038/ncb3052

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OCA

[1] Saisawang C, Wongsantichon J, Ketterman AJ. A preliminary characterization of the cytosolic glutathione transferase proteome from Drosophila melanogaster. Biochem J. 2012 Feb 15;442(1):181-90. doi: 10.1042/BJ20111747. PMID:22082028 doi:http://dx.doi.org/10.1042/BJ20111747

[2] Enya S, Ameku T, Igarashi F, Iga M, Kataoka H, Shinoda T, Niwa R. A Halloween gene noppera-bo encodes a glutathione S-transferase essential for ecdysteroid biosynthesis via regulating the behaviour of cholesterol in Drosophila. Sci Rep. 2014 Oct 10;4:6586. doi: 10.1038/srep06586. PMID:25300303 doi:http://dx.doi.org/10.1038/srep06586

[3] Chanut-Delalande H, Hashimoto Y, Pelissier-Monier A, Spokony R, Dib A, Kondo T, Bohere J, Niimi K, Latapie Y, Inagaki S, Dubois L, Valenti P, Polesello C, Kobayashi S, Moussian B, White KP, Plaza S, Kageyama Y, Payre F. Pri peptides are mediators of ecdysone for the temporal control of development. Nat Cell Biol. 2014 Nov;16(11):1035-44. doi: 10.1038/ncb3052. Epub 2014 Oct 26. PMID:25344753 doi:http://dx.doi.org/10.1038/ncb3052

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