Uridine phosphorylase

Function Uridine phosphorylase (UPP) catalyzes the conversion of uridine or deoxyuridine and phosphate to uracil and α-D-ribose 1-phosphate. UPP is part of RNA or DNA biosynthesis. Unhydrouridine is an inhibitor of UPP. Relevance UPP inhibitors are tested for prevention of mucositis during chemotherapy. Structural highlights The . Water molecule is shown as red sphere. = 3D Structures of uridine phosphorylase Uridine phosphorylase 3D structures

spinqualitylabelsall models Structure of uridine phosphorylase complex with fluorouracil, glycerol, ethylene glycol and K+ ion (purple) (PDB code 4e1v). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of uridine phosphorylase3D Structures of uridine phosphorylase

Updated on 23-March-2020

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• Uridine phosphorylase
  • 1k3f, 1lx7, 1rxy, 1t0u – EcUPP – Escherichia coli
    
  • 1ryz, 2iq5, 2oxf, 2qdk, 3dps – StUPP – Salmonella typhimurium
    
  • 3o6v, 4k6o, 6eyp – VcUPP – Vibrio cholerae
    
  • 4i2v, 4ny1, 4of4 – UPP – Yersinia pseudotuberculosis
    
  • 4txh – SmUPP – Schistosoma mansoni
    
  • 6k5g, 6k5h, 6k5k, 6k8p, 6kd3 – UPP – Phytophthora capsici
    
• Uridine phosphorylase binary complex
  • 3ku4 – bUPP + sulfate - bovine
    
  • 1sj9, 2hsw, 2i8a, 3ddo – StUPP + phosphate
    
  • 1y1t – StUPP + sulfate
    
  • 2oec, 3c74 – StUPP + inhibitor
    
  • 4g8j – StUPP + 2’-deoxythymidine
    
  • 4e1v, 4ogk, 4ogl – SeUPP + nucleotide – Salmonella enterica
    
  • 4lnh – VfUPP + sulfate – Vibrio fischeri
    
  • 4h1t, 4ip0 – VcUPP + phosphate
    
  • 5epu – VcUPP + cytosine
    
  • 5our – VcUPP + anhydrouridine
    
  • 4lzw, 4oeh, 5c80, 5epu, 5efo, 5m2t – VcUPP + nucleotide
    
  • 4u2k – VcUPP + anticancer compound
    
  • 4txj, 4txl, 4txn, 4txm – SmUPP + nucleotide
    
  • 4jp5 – UPP + sulfate – Yersinia pestis
    
  • 4r2x – SoUPP + sulfate – Shewanella oneidensis
    
  • 4yjk – SoUPP (mutant) + uracil
    
• Uridine phosphorylase ternary complex
  • 3kuk – bUPP + sulfate + 2’-deoxyuridine
    
  • 3kvr – bUPP + sulfate + 5-fluorouracil
    
  • 3kvy – bUPP + sulfate + uracil
    
  • 1y1r, 1zl2, 2pga, 3fwp – StUPP + phosphate + inhibitor
    
  • 2rj3 – StUPP + phosphate + uracil
    
  • 1y1s – StUPP + sulfate + uracil
    
  • 1y1q – StUPP + sulfate + UMP
    
  • 2hn9, 2hrd – StUPP + phosphate + thymine
    
  • 2hwu – StUPP + phosphate + uridine
    
  • 1rxs – EcUPP + phosphate + 2’-deoxyuridine <br /
  • 1rxu – EcUPP + phosphate + 2’-deoxythymidine
    
  • 1tgy – EcUPP + ribose-1-phosphate + uracil
    
  • 1u1c, 1u1d, 1u1e, 1u1f, 1u1g – EcUPP + phosphate + 5-substituted acyclouridine
    
  • 1tgv – EcUPP + sulfate + 5-fluorouridine
    
  • 3kvv – EcUPP + sulfate + 5-fluorouracil
    
  • 1rxc – EcUPP + ribose-1-phosphate + phosphate + 5-fluorouracil + 5-fluorouridine
    
  • 3pns, 5miw – VcUPP + sulfate + uracil
    
  • 5lhv – VcUPP + sulfate + uridine
    
  • 5efo, 5lok – VcUPP + cytosine + cytidine
    
  • 4mch – VfUPP + sulfate + hydroxyl naphthoic acid
    
  • 4mci – VfUPP + sulfate + DMSO
    
  • 4r2w – SoUPP + sulfate + uridine
    
  • 4yjk – SoUPP (mutant) + sulfate + uracil
    
  • 3qpb – UPP + ribose-1-phosphate + uracil – Streptococcus pyogenes
    
• Human uridine phosphorylase
  • 3eue – hUPP 1 + sulfate - human
    
  • 3euf – hUPP 1 + benzylacyclouridine
    
  • 3nbq – hUPP 1 + 5-fluorouracil
    
  • 2xrf – hUPP 2 + uracil
    
  • 3p0f – hUPP 2 + benzylacyclouridine
    
  • 3p0e – hUPP 2 + phosphate + benzylacyclouridine