5k20

Caspase-7 S239E PhosphomimeticCaspase-7 S239E Phosphomimetic

Structural highlights

5k20 is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	3ibf, 3s8e, 1k86, 3r5k
Activity:	Caspase-7, with EC number 3.4.22.60
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

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OCA