4js2

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Crystal structure of human Beta-galactoside alpha-2,6-sialyltransferase 1 in complex with CMPCrystal structure of human Beta-galactoside alpha-2,6-sialyltransferase 1 in complex with CMP

Structural highlights

4js2 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , ,
Gene:ST6GAL1, SIAT1 (HUMAN)
Activity:Beta-galactoside alpha-2,6-sialyltransferase, with EC number 2.4.99.1
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SIAT1_HUMAN] Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.[1]

References

  1. Wu ZL, Ethen CM, Prather B, Machacek M, Jiang W. Universal phosphatase-coupled glycosyltransferase assay. Glycobiology. 2011 Jun;21(6):727-33. doi: 10.1093/glycob/cwq187. Epub 2010 Nov, 15. PMID:21081508 doi:10.1093/glycob/cwq187

4js2, resolution 2.30Å

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