Neurophysin

Function Neurophysins are carrier proteins which transport hormones from the hypothalamus to the posterior pituitary gland. Neurophysin-1 transports oxytocin. Neurophysin-2 transports vasopressin. Oxytocin is used to start labor and increase its speed. Vasopressin functions to retain water in the body and to constrict blood vessels. Disease Mutations in neurophysin-2 are associated with familial diabetes. Structural highlights .

spinqualitylabelsall models Neurophysin-2 (green and cyan) complex with oxytocin (magenta and salmon) (PDB code 1npo) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of neurophysin3D Structures of neurophysin

Updated on 13-August-2018

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• Neurophysin-1
  • 2lbh, 2lbn – bNP1 – bovine - NMR
    
  • 1l5c, 1l5d – bNP1 (mutant) - NMR
    
  • 2hnw – bNP1 (mutant)
    
  • 2hnu, 2hnv – bNP1 (mutant) + dipeptide
    
• Neurophysin-2
  • 1jk6 – bNP2
    
  • 1npo – bNP2 + oxytocin
    
  • 1jk4 – bNP2 + Lys vasopressin
    
  • 2bn2 – bNP2 + dipeptide