Cysteine desulfurase

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Function

Cysteine desulfurase (SUFS) catalyzes the conversion of L-cysteine to L-alanine and sulfane sulfur. SUFS has a role in the biosynthesis of Fe-S custers, thiamine, thionucleosides, biotin, lipoic acid, molybdopterin and NAD[1]. SUFS is a PLP-dependent enzyme.

Structural highlights

The structure of SUFS contains the .

  • .

. The reaction product [2].


Bacterial cysteine desulfurase complex with PLP, mercaptocysteine and alanine (PDB code 5j8q)

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3D structures of cysteine desulfurase3D structures of cysteine desulfurase

Updated on 06-November-2018

ReferencesReferences

  1. ↑ Mihara H, Esaki N. Bacterial cysteine desulfurases: their function and mechanisms. Appl Microbiol Biotechnol. 2002 Oct;60(1-2):12-23. doi:, 10.1007/s00253-002-1107-4. Epub 2002 Sep 4. PMID:12382038 doi:http://dx.doi.org/10.1007/s00253-002-1107-4
  2. ↑ Blauenburg B, Mielcarek A, Altegoer F, Fage CD, Linne U, Bange G, Marahiel MA. Crystal Structure of Bacillus subtilis Cysteine Desulfurase SufS and Its Dynamic Interaction with Frataxin and Scaffold Protein SufU. PLoS One. 2016 Jul 6;11(7):e0158749. doi: 10.1371/journal.pone.0158749., eCollection 2016. PMID:27382962 doi:http://dx.doi.org/10.1371/journal.pone.0158749

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