Collagenase (non-MMP)

Collagenase (Col) catalyzes the breaking of peptide bonds in collagen. Col cleaves pro-collagen to create collagen. Some collagenases are part of the Matrix metalloproteinase family. Relevance Col is used for therapy of wounds, Dupuytren's contracture and Peyronie's disease. Structural highlights Clostridium histolycum collagenase contains several domains among them: peptidase domain (residues 331-721), polycystic kidney disease domain (PKD residues 792-880), collagen-binding domain (CBD residues 1003-1118). The peptidase domain contains a , a and an . Water molecules are shown as red spheres. . 3D Structures of collagenase Collagenase 3D structures

spinqualitylabelsall models Collagenase H peptidase domain (cyan) complex with peptidic inhibitor, isopentenyl phosphate, Ca+2 (green) and Zn+2 (grey) ions (PDB entry 4arf) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of collagenase3D Structures of collagenase

Updated on 14-May-2019

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• Collagenase G
  • 2y3u, 2y50 – ChColG residues 119-880 – Clostridium histolycum
    
  • 4are - ChColG residues 119-790
    
  • 2y6i - ChColG residues 119-880 + peptide
    
  • 4jrw, 4tn9, 4aqo, 2y72 - ChColG PKD domain
    
  • 1nqj - ChColG CBD domain
    
  • 1nqd, 2o8o, 4hpk, 5iku - ChColG CBD domain + Ca
    
• Collagenase H
  • 4u6t - ChColH PKD domain
    
  • 4jgu, 4u7k - ChColH PKD domain + Ca
    
  • 3jqw, 3jqx - ChColH CBD domain + Ca
    
  • 4ar1 – ChColH peptidase domain
    
  • 4arf – CtColH peptidase domain + peptide inhibitor
    
  • 5o7e – ColH peptidase domain + inhibitor – Hathewaya histolytica
    
• Collagenase T
  • 4ar9 – CtColT peptidase domain - Clostridium tetani
    
  • 4ar8 – CtColT peptidase domain + peptide inhibitor
    
• Collagenase
  • 1azz – Col + ecotin – fiddler crab
    
  • 1hyl, 2hlc – Col – Hypoderma lineatum
    
  • 5sv5 – Col C-terminal – Bacillus anthracis
    
• Collagenase 3 or matrix metalloproteinase 13 see Matrix metalloproteinase