5v3c

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Crystal structure of TGT in complex with 4-(aminomethane)cyclohexane-1-carboxylic acidCrystal structure of TGT in complex with 4-(aminomethane)cyclohexane-1-carboxylic acid

Structural highlights

5v3c is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , ,
Activity:tRNA-guanine(34) transglycosylase, with EC number 2.4.2.29
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]

5v3c, resolution 1.42Å

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OCA