Bungarotoxin

Bungarotoxins. α-Bungarotoxin (α-BGT), β-Bungarotoxin (β-BGT), γ-Bungarotoxin (γ-BGT) and κ-Bungarotoxin (κ-BGT) are snake toxins from banded krait. α-BGT binds irreversibly to the acetylcholine receptor (AChR) causing paralysis and death. See details in Alpha-bungarotoxin. β-BGT binds to the presynaptic terminal causing release of acetylcholine. γ-BGT inhibits the binding of quinoclidinyl bezilate to the M2 muscarinic acetylcholine receptor. κ-BGT binds weakly to the nicotinic acetylcholine receptor. For toxins in Proteopedia see Toxins. in α-Bungarotoxin (PDB code 1hc9). Water molecule shown as red sphere. 3D Structures of Bungarotoxin Bungarotoxin 3D structures

spinqualitylabelsall models α-Bungarotoxin (green) complex with peptide derived from acetylcholine receptor (yellow) and I- ion (PDB code 1hc9) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Bungarotoxin3D Structures of Bungarotoxin

Updated on 18-April-2019

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• Bungarotoxin
  • 2abx – α-BGT
    
  • 1kfh, 1ik8, 1ikc, 1idi, 1idl, 2nbt – α−BGT – NMR
    
  • 1bun - β2-BGT
    
  • 1mr6 – γ-BGT – NMR
    
  • 1kba – κ-BGT
    
• BGT+binding peptide
  • 1l4w, 1ljz, 1kc4, 1kl8, 1jbd, 1haa, 1haj, 1idg, 1idh, 1hoy, 1bxp, 1abt, 1rgj, 2btx – α-BGT+AChR peptide - NMR
    
  • 1hc9 - α-BGT+AChR peptide
    
• BGT+ AChR subunit
  • 2qc1 – α-BGT+mAChR α subunit
    
  • 5hbt - α-BGT+ hAChR α1 subunit + antibody
    
  • 5hbv - α-BGT+ mAChR α1 subunit + antibody
    
  • 4hqp - α−BGT+ hAChR α7 subunit
    
  • 4uy2 - α−BGT+ hAChR α9 subunit
    

ReferencesReferences

Alpha-bungarotoxin