4olf

Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase)from Plasmodium falciparum in complex with Halofuginone and AMPPNPCrystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase)from Plasmodium falciparum in complex with Halofuginone and AMPPNP

Structural highlights

4olf is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , , ,
Related:	4ncx
Activity:	Proline--tRNA ligase, with EC number 6.1.1.15
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SYP_PLAF7] Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity). Functions in trans to edit the amino acid moiety from incorrectly charged Ala-tRNA(Pro). Has no activity on correctly charged Pro-tRNA(Pro) or Ala-tRNA(Ala).^[1]

References

↑ Ahel I, Korencic D, Ibba M, Soll D. Trans-editing of mischarged tRNAs. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15422-7. Epub 2003 Dec 8. PMID:14663147 doi:http://dx.doi.org/10.1073/pnas.2136934100

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OCA

[1] Ahel I, Korencic D, Ibba M, Soll D. Trans-editing of mischarged tRNAs. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15422-7. Epub 2003 Dec 8. PMID:14663147 doi:http://dx.doi.org/10.1073/pnas.2136934100

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