14-3-3 protein

Function 14-3-3 proteins (PRS) are conserved regulatory proteins which bind to a multitude of signaling proteins like kinases phosphatases and transmembrane receptors. The name 14-3-3 derives from their elution pattern via chromatography. Disease Elevated levels of PRS are found in patients with Creutzfeld-Jakob disease (CJD). PRS are associated with Parkinson Disease (PD) and with Alzheimer Disease (AD) based on their localization and their binding to PD and AD-associated proteins. Relevance PRS are tested as biomarkers for CJD, PD and AD. Structural highlights PRS are homo- and heterodimers containing . (3 helices of chain A are in red and 3 helices of chain B are in magenta). . 3D structures of 14-3-3 protein 14-3-3 protein 3D structures

spinqualitylabelsall models Structure of human 14-3-3 protein ζ with phosphopeptide (yellow) (PDB code 1qja). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of 14-3-3 proteins (Updated on 20-February-2019)3D structures of 14-3-3 proteins (Updated on 20-February-2019)

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• 14-3-3 protein σ
  • 1yz5 – hPRS – human
    
• 14-3-3 protein σ binary complex with peptide
  • 1ywt, 5mhc – hPRS + phosphopeptide
    
  • 3lw1, 5moc, 5mxo – hPRS + p53 peptide
    
  • 3iqj, 3iqu, 4iea – hPRS + Raf-1 peptide
    
  • 3mhr – hPRS + YAP peptide
    
  • 3p1n – hPRS + TASK-3 peptide
    
  • 3p1p, 3p1r – hPRS (mutant) + TASK-3 peptide
    
  • 4dat, 4dau – hPRS + PADI6 peptide
    
  • 4jc3, 4jdd – hPRS + estrogen receptor peptide
    
  • 4fl5, 5btv, 5hf3, 4y5i, 4y32, 4y3b – hPRS + τ protein peptide
    
  • 5ltw – hPRS (mutant) + HSPB6
    
  • 5lu1, 5lu2 – hPRS (mutant) + HSPB6 peptide
    
  • 4qli – hPRS + SNAI1 peptide
    
  • 5my9, 5myc – hPRS + LRRK2 peptide
    
  • 5n5r, 5n5t, 5n5w, 5n75 – hPRS + taz ps89 peptide
    
  • 5ok9, 5okf – hPRS/HSPB6
    
  • 5om0 – hPRS/GLI1
    
  • 5oma – hPRS/STRAD1 + peptide
    
• 14-3-3 protein σ binary complex with small molecule
  • 3u9x – hPRS + pyridoxal phosphate
    
  • 3t0l, 3t0m, 4dhm, 4dhn, 4dho, 4dhp, 4dhq, 4dhr, 4dhs, 4dht, 4dhu – hPRS + inhibitor
    
  • 5oeh, 5oeg – hPRS + molecular tweezers
    
• 14-3-3 protein σ ternary complex with stabilizer
  • 3p1o, 3ux0, 4fr3 – hPRS + TASK-3 peptide + stabilizer
    
  • 3p1q, 3p1s, 3spr, 3smk, 3sml, 3smm, 3smn, 3smo, 3sp5 – hPRS (mutant) + TASK-3 peptide + stabilizer
    
  • 3iqv, 3o8i – hPRS + Raf-1 peptide + stabilizer
    
• 14-3-3 protein ζ
  • 1a4o – bPRS - bovine
    
  • 1a37 – bPRS + Raf peptide
    
  • 1a38 – bPRS + R18 peptide
    
  • 1qja – hPRS + phosphopeptide
    
  • 4wrq – hPRS + Chibby peptide
    
• 14-3-3 protein ζ/δ
  • 3rdh – hPRS
    
  • 3rdh – hPRS/LKB1
    
  • 1qjb, 1qja, 6eww – hPRS + phosphopeptide
    
  • 2c1j, 2c1n – hPRS + histone H3 peptide
    
  • 2o02, 4n7g, 4n7y, 4n84, 5j31 – hPRS + exoenzyme S peptide
    
  • 2v7d, 4hkc – hPRS + integrin peptide
    
  • 5jm4 – hPRS + peptide
    
  • 5nas – hPRS + PI4KIIIB peptide
    
  • 5m35, 5m36, 5m37 – hPRS + M-phase phosphatase peptide
    
  • 5ulo – hPRS + TBC1D7 peptide
    
  • 6ejl – hPRS + MAP3K 5 peptide
    
  • 6f08 – hPRS + SOS-1 peptide
    
  • 3cu8, 3nkx, 4fj3, 4ihl – hPRS + Raf-1 peptide
    
  • 2wh0 – hPRS + protein kinase C ε peptide
    
  • 4bg6 – hPRS + RND3 peptide
    
  • 5ewz, 5exa – hPRS + GRB2-associated protein peptide
    
  • 5d2d – hPRS + CFTR peptide
    
  • 5d3f – hPRS + CFTR peptide + stabilizer
    
  • 1ib1 – hPRS + serotonin N-acetyltransferase
    
• 14-3-3 protein γ
  • 4e2e – hPRS
    
  • 2b05 – hPRS + phosphopeptide
    
  • 3uzd – hPRS + histone deacylase peptide
    
  • 4j6s – hPRS + tyrosine hydroxylase peptide
    
  • 4o46 – hPRS + influenza C-terminal peptide
    
  • 5d3e – hPRS + CFTR peptide
    
  • 6fel – hPRS + CAMKK 2 peptide
    
• 14-3-3 protein β/α
  • 2bq0, 4dnk – hPRS
    
  • 2c23 – hPRS + exoenzyme S peptide
    
  • 5n10 – hPRS + estrogen receptor peptide
    
  • 4gnt – mPRS + CHREBP peptide - mouse
    
  • 5f74 – mPRS + CHREBP + AMP
    
• 14-3-3 protein θ
  • 5iqp – hPRS
    
  • 2btp – hPRS + phosphopeptide
    
• 14-3-3 protein η
  • 2c63, 2c74 – hPRS + phosphopeptide
    
  • 5yqg – hPRS + NUMB peptide
    
• 14-3-3 protein ε
  • 2br9, 6eih – hPRS + phosphopeptide
    
  • 3ual, 3ubw – hPRS + myeloid leukemia factor 1 peptide
    
• 14-3-3 protein
  • 3efz – PRS + phosphoserine – Cryptosporidium parvum
    
  • 4f7r – PRS – Giardia intestinalis
    
• 14-3-3-like protein C
  • 1o9c, 1o9e – tPRS - tobacco
    
  • 1o9d, 1o9f, 2o98, 3e6y – tPRS + H+ ATPase peptide
    
  • 5nwi, 5nwj, 5nwk – tPRS + potassium channel peptide
    
  • 3m50, 3m51 – tPRS + PMA2 peptide + stabilizer
    
• 14-3-3-like protein GF14-C
  • 3axy – PRS + HD3A + OSFD1 - rice
    
• 14-3-3-like protein E
  • 4dx0 – tPRS + PMA2 peptide + stabilizer