Proteopedia

Gramicidin

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Function

Gramicidin (GCDN) is a polypeptide composed of alternating L- and D-amino acids. It is produced by the bacteria Bacillus brevis[1].

  • GCDN S is an antibiotic cyclic polypeptide.
  • GCDN D is a mixture of GCDN A, B, C.

See theoretical model of Gramicidin Channel in Lipid Bilayer.

Relevance

GCDN has bactericidal activity and is used as a topical antibiotic and as topical contraceptive[2].

Structural highlights: Gramicidin A

Protein:

, chain A in green, chain B in salmon.

Non-standard residues:

Ligands:

, C atom of methanol in cyan.

, C atom of thiocyanate in magenta.

(in purple).

Gramicidin A complex with thiocyanate and K+ ion (purple) (PDB entry 1gmk)

Drag the structure with the mouse to rotate

3D Structures of Gramicidin3D Structures of Gramicidin

Updated on 20-October-2017

ReferencesReferences

  1. ↑ Urry DW, Goodall MC, Glickson JD, Mayers DF. The gramicidin A transmembrane channel: characteristics of head-to-head dimerized (L,D) helices. Proc Natl Acad Sci U S A. 1971 Aug;68(8):1907-11. PMID:5288776
  2. ↑ Kondejewski LH, Farmer SW, Wishart DS, Hancock RE, Hodges RS. Gramicidin S is active against both gram-positive and gram-negative bacteria. Int J Pept Protein Res. 1996 Jun;47(6):460-6. PMID:8836773

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Michal Harel, Alexander Berchansky, Joel L. Sussman
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