Protein phosphatase

Function Protein phosphatases (PP) or serine/threonine protein phosphatase regulate protein phosphorylation and thus are key in intracellular signal transduction processes. PP1 is a serine/threonine phosphatase and is a key component of the insulin signaling pathway. PP2A targets proteins in the oncogenic signaling pathways. For PP2A see also HEAT Repeat. PP2C are Mg/Mn-dependent and are essential for the regulation of cell cycle and stress signaling pathways. For details see ABA-regulated Protein Phosphatase 2C and ABA Signaling_pathway. PP4 regulates a variety of cellular functions. PP5 is activated by lipids and is involved in signal transduction. Disease Mutations in PP2A are found in many solid cancers and leukemias. PP2A-activating drugs are possible candidates for cancer therapeutics protocols. Development of Alzheimer disease drugs could be based on restoration of PP2A activity. Structural highlights . Algal toxin binds at the surface pocket of the PP2A catalytic subunit which contains the Mn+2 ion cofactors. Water molecule shown as red sphere. . .

spinqualitylabelsall models Human PP2A catalytic (green) and regulatory (cyan) subunits complex with tumor-inducing toxin and sulfate 3k7v Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of protein phosphatase3D Structures of protein phosphatase

Updated on 01-January-2019

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• Protein phosphatase 1
  • 2rlt - PP1 regulatory subunit - pig - NMR
    
• Protein phosphatase 1A
  • 3fxj, 3fxk, 3fxl, 3fxm, 3fxo, 4ra2 – hPP1A + Mn – human
    
  • 3n5u – hPP1A catalytic subunit + retinoblastoma-associated protein
    
  • 4g9j, 5ioh – hPP1A catalytic subunit + peptide
    
• Protein phosphatase 1G
  • 5inb, 5j28 - hPP1G catalytic subunit + peptide
    
• Protein phosphatase 1K
  • 4da1 - hPP1K + Mn
    
• Protein phosphatase 2A
  • 1b3u, 2g62, 2hv6 – hPP2A regulatory subunit
    
  • 2ie3, 2ie4, 2npp, 2nyl, 2nym – hPP2A catalytic + regulatory subunit + tumor-inducing toxin
    
  • 3c5w – hPP2A catalytic + regulatory subunit + PP2A-specific methyltransferase
    
• Protein phosphatase 2B See Calcineurin
• Protein phosphatase 2C
  • 2iq1 – hPP2C κ
    
  • 4raf, 4rag - hPP2C α (mutant) + Mn
    
  • 3d8k – PP2C – Toxoplasma gondii
    
  • 3jrq, 3nmn – AtPP2C + Pyl1 + pyrabactin – Arabidopsis thaliana
    
  • 3kdj - AtPP2C + Pyl1 + abscicic acid
    
  • 3nmt, 3kb3, 3nmv, 3ujl – AtPP2C + Pyl2
    
  • 4la7, 4lg5, 4lga, 4lgb – AtPP2C + Pyl2 + ligand
    
  • 4ds8, 5jo1, 5jo2 – AtPP2C + Pyl3 + Mn
    
  • 3rt0 – AtPP2C (mutant) + Pyl10
    
  • 4n0g – AtPP2C + Pyl13
    
  • 3qn1, 3zvu, 4wvo – AtPP2C + Pyr1
    
  • 3ujk – AtPP2C
    
  • 4yzg – AtPP2C (mutant)
    
  • 4yzh – AtPP2C (mutant) + chlorophyll-binding protein peptide
    
  • 3ujg - AtPP2C + SRK2E
    
• Protein phosphatase 4
  • 4wsf – PP4 regulatory subunit + Cenp-C – Drosophila melanogaster
    
• Protein phosphatase 5
  • 1wao – hPP5 + Mn
    
  • 5muf – hPP5
    
  • 1a17 – hPP5 protein-interacting domain
    
  • 2bug – hPP5 protein-interacting domain (mutant) + Hsp90 peptide - NMR
    
  • 1s95, 3h60 – hPP5 catalytic domain + Mn
    
  • 3h61, 3h62, 3h63, 3h64, 3h66, 3h67, 3h68, 3h69, 4zvz, 4zx2, 4zvz, 4zx2 – hPP5 catalytic domain + inhibitor + Mn
    
  • 5hpe – hPP5 catalytic domain/Hsp90 peptide + Mn
    
  • 4ja7, 4ja9 - rPP5 catalytic domain + inhibitor
    
  • 3icf - yPP5 catalytic domain + Fe - yeast
    
  • 5jjt – AtPP5 + Ni
    
• Protein phosphatase
  • 1g5b – PP + Mn – Enterobacteria phage λ
    
  • 2pk0 – PP + Mg – Streptococcus agalactiae
    
  • 2cm1 – PP + Mn – Mycobacterium tuberculosis
    
  • 3pu9 – PP + Mg – Sphaerobacter thermophilus
    
  • 5f1m – PP Stp1 + Mn – Staphylococcus aureus
    
  • 5jpf – PP Z1 + microcystin-LR + Mn – Candida albicans