Protein Nef

Function Protein Nef (Nef) or negative regulatory factor is an HIV and SIV accessory protein which establishes a persistent state of infection. Nef downmodulates the surface levels of molecules at the immune synapse. For more details see HIV and accessory proteins.

spinqualitylabelsall models HIV-I protein Nef (grey) complex with tyrosine protein kinase Hck SH3 domain (green) and ethanediol (PDB code 3rbb) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of protein Nef3D Structures of protein Nef

Updated on 29-August-2018

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• Protein Nef from HIV; domains – anchor 1-57; core 58-207
  • 3tb8, 2xi1 – Nef – HIV-1
    
  • 1qa5, 1qa4 – Nef anchor domain – NMR
    
  • 1avv, 6b72 – Nef core domain
    
  • 2nef – Nef core domain (mutant) – NMR
    
• Protein Nef from HIV complex
  • 4u5w, 3rbb – Nef core domain + tyrosine protein kinase Hck
    
  • 3rea, 3reb – Nef core domain (mutant) + tyrosine protein kinase Hck
    
  • 4d8d, 1avz, 1efn – Nef core domain + tyrosine protein kinase Fyn
    
  • 4orz – Nef core domain + tyrosine protein kinase Hck + single domain antibody
    
  • 4u5w - Nef core domain + tyrosine protein kinase Hck SH3-SH2 domain
    
  • 4nee – Nef core domain + adapter-related protein complex 2 subunits σ, α-2
    
  • 4emz, 4en2 – Nef + adapter-related protein complex 1 subunit μ-1 + MHC-I
    
• Protein Nef from SIV
  • 3ik5, 3ioz – Nef core domain + CD3 ζ
    
  • 5nuh - Nef core domain + tyrosine protein kinase Hck SH3 domain
    
  • 5nui - Nef core domain + polypeptide