5k22

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Crystal structure of the complex between human PRL-2 phosphatase in reduced state and Bateman domain of human CNNM3Crystal structure of the complex between human PRL-2 phosphatase in reduced state and Bateman domain of human CNNM3

Structural highlights

5k22 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Activity:Protein-tyrosine-phosphatase, with EC number 3.1.3.48
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TP4A2_HUMAN] Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.[1] [CNNM3_HUMAN] Probable metal transporter.

References

  1. ↑ Werner SR, Lee PA, DeCamp MW, Crowell DN, Randall SK, Crowell PL. Enhanced cell cycle progression and down regulation of p21(Cip1/Waf1) by PRL tyrosine phosphatases. Cancer Lett. 2003 Dec 30;202(2):201-11. PMID:14643450

5k22, resolution 3.00Å

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OCA
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