4x5h

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ecDHFR complexed with folate and NADP+ at 500 MPaecDHFR complexed with folate and NADP+ at 500 MPa

Structural highlights

4x5h is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Activity:Dihydrofolate reductase, with EC number 1.5.1.3
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

4x5h, resolution 1.90Å

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OCA
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