6el3

Structure of Progesterone 5beta-Reductase from Arabidopsis thaliana in complex with NADPStructure of Progesterone 5beta-Reductase from Arabidopsis thaliana in complex with NADP

Structural highlights

6el3 is a 6 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
NonStd Res:
Activity:	Delta(4)-3-oxosteroid 5-beta-reductase, with EC number 1.3.1.3
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[VEP1_ARATH] Involved in vascular strand development. Catalyzes the stereospecific conversion of progesterone to 5-beta-pregnane-3,20-dione. Can use progesterone, testosterone, 21-acetyl cortexone, 2-cyclohexenone, but-1-en-3-one, ethyl acrylate, ethylmethacrylate, cortisone and canarigenone as substrates, lower activity with 3-methyl-2-cyclohexenone and 3,5,5-trimethyl-2-cyclohexenone as substrate, and no activity with canarigenin, canarigenin digitoxoside and pregnenolone. May be involved in the formation of 5-beta phytoecdysteroids.^[1] ^[2]

References

↑ Jun JH, Ha CM, Nam HG. Involvement of the VEP1 gene in vascular strand development in Arabidopsis thaliana. Plant Cell Physiol. 2002 Mar;43(3):323-30. PMID:11917087
↑ Herl V, Fischer G, Reva VA, Stiebritz M, Muller YA, Muller-Uri F, Kreis W. The VEP1 gene (At4g24220) encodes a short-chain dehydrogenase/reductase with 3-oxo-Delta4,5-steroid 5beta-reductase activity in Arabidopsis thaliana L. Biochimie. 2009 Apr;91(4):517-25. doi: 10.1016/j.biochi.2008.12.005. Epub 2009, Jan 10. PMID:19166903 doi:http://dx.doi.org/10.1016/j.biochi.2008.12.005

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OCA

[1] Jun JH, Ha CM, Nam HG. Involvement of the VEP1 gene in vascular strand development in Arabidopsis thaliana. Plant Cell Physiol. 2002 Mar;43(3):323-30. PMID:11917087

[2] Herl V, Fischer G, Reva VA, Stiebritz M, Muller YA, Muller-Uri F, Kreis W. The VEP1 gene (At4g24220) encodes a short-chain dehydrogenase/reductase with 3-oxo-Delta4,5-steroid 5beta-reductase activity in Arabidopsis thaliana L. Biochimie. 2009 Apr;91(4):517-25. doi: 10.1016/j.biochi.2008.12.005. Epub 2009, Jan 10. PMID:19166903 doi:http://dx.doi.org/10.1016/j.biochi.2008.12.005

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