FunctionThe virus contains a surface glycoprotein PG that is responsible for binding to target cells and subsequent fusion of viral and host-cell membranes. GP is expressed as a single-chain precursor that is posttranslationally processed into disulfide-linked fragments of GP1 and GP2 [1]. Viral infections is initiated by interactions between the viral protein glycoprotein PG1 and its cognate receptor. The GP2 subunit is thought to mediate membrane fusion.
For details see GP1 of Lassa Virus.
DiseaseRelevanceStructural highlights | |
3D Structures of glycoprotein GP3D Structures of glycoprotein GP
Updated on 08-January-2018
{"openlevels":0}
- Glycoprotein GP
- 2wfo – MvGP1 – Machupo virus
- 4zjf – GP1 – Lassa virus
- 5nff – GP1 – Morogoro virus
- 5nsj – GP1 – Whitewater arroyo mammarenavirus
- 3lj5, 4v4k – GP1 – Bacteriophage p22
- Glycoprotein GP complex
- 3ve0, 3s88 – GP1 + GP2 + antibody – Sudan ebolavirus
- 5f1b – ZevGP1 + GP2 + Niemann-Pick C1 protein – Zaire ebolavirus
- 6f5u, 6f6i, 6f6n, 6f6s – ZevGP1 + GP2 + antidepressant
- 3csy, 5kel, 5ken – ZevGP1 + GP2 + antibody
- 5uqy – GP1 + GP2 + antibody – Marburg virus
- 3kas – MvGP1 + transferrin receptor 1
- 5nuz – GP1 + antibody – Junin virus
ReferencesReferences
- ↑ Malashkevich VN, Schneider BJ, McNally ML, Milhollen MA, Pang JX, Kim PS. Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2662-7. PMID:10077567
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
Michal Harel