2a6j

Crystal structure analysis of the anti-arsonate germline antibody 36-65Crystal structure analysis of the anti-arsonate germline antibody 36-65

Structural highlights

2a6j is a 4 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	2a6i, 2a6d
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The limited primary antibody repertoire uses multiple mechanisms to account for the large number of potential antigens. In this issue of Immunity, Sethi et al. (2006) describe a new means for expanding the antibody repertoire, whereby a single antibody isomer binds diverse antigens at different regions of the binding site.

Multiple paths to multispecificity.,Mariuzza RA Immunity. 2006 Apr;24(4):359-61. PMID:16618592^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Mariuzza RA. Multiple paths to multispecificity. Immunity. 2006 Apr;24(4):359-61. PMID:16618592 doi:http://dx.doi.org/10.1016/j.immuni.2006.03.009

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OCA

[1] Mariuzza RA. Multiple paths to multispecificity. Immunity. 2006 Apr;24(4):359-61. PMID:16618592 doi:http://dx.doi.org/10.1016/j.immuni.2006.03.009

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