Phospholipase A1

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Function

Phospholipase A1 (PLA1) hydrolyzes phospholipids to produce 2-acyl-lysophospholipids and fatty acids[1]. PLA1 preferentially hydrolyzes phosphatidic acid and PLA1-phosphatidic acid regulates mitochondria dynamics[2].


Disease

Relevance

Structural highlights

Caption for this structure

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3D Structures of phospholipase A13D Structures of phospholipase A1

Updated on 17-January-2018

2yij – PLA1 IIγ – Arabidopsis thaliana
4hyq – PLA1 – Streptomyces albidoflavus
4qnn – PLA1 – hornet
5dqx – PLA1 – Salmonella typhi

ReferencesReferences

  1. ↑ Tani K, Kogure T, Inoue H. The intracellular phospholipase A1 protein family. Biomol Concepts. 2012 Oct;3(5):471-8. doi: 10.1515/bmc-2012-0014. PMID:25436551 doi:http://dx.doi.org/10.1515/bmc-2012-0014
  2. ↑ Baba T, Kashiwagi Y, Arimitsu N, Kogure T, Edo A, Maruyama T, Nakao K, Nakanishi H, Kinoshita M, Frohman MA, Yamamoto A, Tani K. Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics. J Biol Chem. 2014 Apr 18;289(16):11497-511. doi: 10.1074/jbc.M113.531921. Epub, 2014 Mar 5. PMID:24599962 doi:http://dx.doi.org/10.1074/jbc.M113.531921

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Michal Harel, Joel L. Sussman
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