2bpy
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| , resolution 1.9Å | |||||||
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| Ligands: | |||||||
| Gene: | HIV-1 PROTEASE FROM THE NY5 ISOLATE (Human immunodeficiency virus 1) | ||||||
| Activity: | Deleted entry, with EC number 3.4.13.16 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HIV-1 PROTEASE-INHIBITOR COMPLEX
OverviewOverview
The ability to replace an inhibitor bound to the HIV-1 protease in single crystals with other potent inhibitors offers the possibility of investigating a series of protease inhibitors rapidly and conveniently with the use of X-ray crystallography. This approach affords a fast turnaround of structural information for iterative rational drug designs and obviates the need for studying the complex structures by co-crystallization. The replacement approach has been successfully used with single crystals of the HIV-1 protease complexed with a weak inhibitor. The structures of the complexes obtained by the replacement method are similar to those determined by co-crystallization.
About this StructureAbout this Structure
2BPY is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
ReferenceReference
Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme., Munshi S, Chen Z, Li Y, Olsen DB, Fraley ME, Hungate RW, Kuo LC, Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):1053-60. PMID:9757136
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