Membrane-bound mouse CD28 cytoplasmic tailMembrane-bound mouse CD28 cytoplasmic tail

Structural highlights

2nae is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CD28_MOUSE] Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation.[UniProtKB:P10747]

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OCA