FunctionContactin (CNTN) is a neuronal cell surface glycoprotein which associates with sodium channel and enhances the density of these channels on the plasma membrane in mammalian expression systems[1].
Diseasecontactin-4 is an autism susceptibility locus[2].
RelevanceStructural highlights | |
3D structures of contactin3D structures of contactin
Updated on 29-January-2017
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- Contactin-1
- 5e53 – CNTN FN1-FN3 domains – chicken
- 3s97 – hCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase zeta - human
- 2ee2 – hCNTN FN3 domains - NMR
- Contactin-2
- 5e7l – mCNTN FN1-FN3 domains – mouse
- 2om5 – hCNTN Ig1-Ig4 domains
- Contactin-3
- 5e4q – mCNTN FN1-FN3 domains
- 5i99 – mCNTN Ig5-FN2 domains
- 5e5r – mCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase gamma
- Contactin-4
- 5e4s – mCNTN FN1-FN3 domains
- 3jxa – mCNTN Ig1-Ig4 domains
- 3kld – mCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase gamma
- Contactin-5
- 5e4i – mCNTN Ig1-Ig4 domains
- 5e52 – hCNTN FN1-FN3 domains
- 4n68 – hCNTN FN3 domains
- Contactin-6
- 5e55 – mCNTN FN1-FN3 domains
- 5e5u – mCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase gamma
ReferencesReferences
- ↑ Rush AM, Craner MJ, Kageyama T, Dib-Hajj SD, Waxman SG, Ranscht B. Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons. Eur J Neurosci. 2005 Jul;22(1):39-49. PMID:16029194 doi:http://dx.doi.org/10.1111/j.1460-9568.2005.04186.x
- ↑ Cottrell CE, Bir N, Varga E, Alvarez CE, Bouyain S, Zernzach R, Thrush DL, Evans J, Trimarchi M, Butter EM, Cunningham D, Gastier-Foster JM, McBride KL, Herman GE. Contactin 4 as an autism susceptibility locus. Autism Res. 2011 Jun;4(3):189-99. doi: 10.1002/aur.184. Epub 2011 Feb 9. PMID:21308999 doi:http://dx.doi.org/10.1002/aur.184
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Michal Harel