1rd8
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| , resolution 3.00Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , and | ||||||
| Gene: | Hemagglutinin (Influenza A virus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Sructure of the 1918 Human H1 Hemagglutinin Precursor (HA0)
OverviewOverview
The 1918 "Spanish" influenza pandemic represents the largest recorded outbreak of any infectious disease. The crystal structure of the uncleaved precursor of the major surface antigen of the extinct 1918 virus was determined at 3.0 angstrom resolution after reassembly of the hemagglutinin gene from viral RNA fragments preserved in 1918 formalin-fixed lung tissues. A narrow avian-like receptor-binding site, two previously unobserved histidine patches, and a less exposed surface loop at the cleavage site that activates viral membrane fusion reveal structural features primarily found in avian viruses, which may have contributed to the extraordinarily high infectivity and mortality rates observed during 1918.
About this StructureAbout this Structure
1RD8 is a Protein complex structure of sequences from Influenza a virus. The following page contains interesting information on the relation of 1RD8 with [Hemagglutinin]. Full crystallographic information is available from OCA.
ReferenceReference
Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus., Stevens J, Corper AL, Basler CF, Taubenberger JK, Palese P, Wilson IA, Science. 2004 Mar 19;303(5665):1866-70. Epub 2004 Feb 5. PMID:14764887
Page seeded by OCA on Thu Mar 20 13:49:59 2008