5l4e

X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with thiopentalX-ray structure of the 2-22' locally-closed mutant of GLIC in complex with thiopental

Structural highlights

5l4e is a 5 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.^[1]

References

↑ Bocquet N, Prado de Carvalho L, Cartaud J, Neyton J, Le Poupon C, Taly A, Grutter T, Changeux JP, Corringer PJ. A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature. 2007 Jan 4;445(7123):116-9. Epub 2006 Dec 10. PMID:17167423 doi:10.1038/nature05371

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OCA

[1] Bocquet N, Prado de Carvalho L, Cartaud J, Neyton J, Le Poupon C, Taly A, Grutter T, Changeux JP, Corringer PJ. A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature. 2007 Jan 4;445(7123):116-9. Epub 2006 Dec 10. PMID:17167423 doi:10.1038/nature05371

[1]

5l4e

X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with thiopentalX-ray structure of the 2-22' locally-closed mutant of GLIC in complex with thiopental

Structural highlights

Function

References

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5l4e

X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with thiopentalX-ray structure of the 2-22' locally-closed mutant of GLIC in complex with thiopental

Structural highlights

Function

References

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