4orb

Crytal structure of mouse calcineurinCrytal structure of mouse calcineurin

Structural highlights

4orb is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Related:	4or9, 4ora, 4orc
Activity:	Phosphoprotein phosphatase, with EC number 3.1.3.16
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[PP2BA_MOUSE] Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L and HSPB1 (By similarity). Dephosphorylates SSH1.^[1] [CANB1_MOUSE] Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

References

↑ Gaestel M, Benndorf R, Hayess K, Priemer E, Engel K. Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase. J Biol Chem. 1992 Oct 25;267(30):21607-11. PMID:1328240

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OCA

[1] Gaestel M, Benndorf R, Hayess K, Priemer E, Engel K. Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase. J Biol Chem. 1992 Oct 25;267(30):21607-11. PMID:1328240

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