Folylpolyglutamate synthase

Function Folypolyglutamate synthase (FPGS) is active in intracellular folate homeostasis. Polyglutamated folates are substrates for generation of the primary metyhl group donor S-adenosylmethionine (SAM). Relevance FPGS status is a predictor of chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate based chemotherapy and FPGS gene transfer may increase the sensitivity of colon cancer cells to 5-FU-based chemotherapy. Structural highlights This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

spinqualitylabelsall models Folypolyglutamate synthase complex with ADP, AMPPCP and Co+2 ion (pink) (PDB code 2vor Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of folypolyglutamate synthase3D structures of folypolyglutamate synthase

Updated on 15-December-2016

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• Folypolyglutamate synthase
  • 3nrs – YpFPGS/dihydrofolate synthase – Yersinia pestis
    
  • 1o5z – FPGS – Thermotoga maritima
    
  • 2gca – LcFPGS – Lactobacillus casei
    
• Folypolyglutamate synthase complex
  • 3qcz – YpFPGS/dihydrofolate synthase + AMPPNP + Mn + glutamate
    
  • 3pyz – YpFPGS/dihydrofolate synthase + AMPPNP + Mn
    
  • 3n2a – YpFPGS/dihydrofolate synthase + ADP + Mg
    
  • 2vor – MtFPGS + ADP + AMPPNP – Mycobacterium tuberculosis
    
  • 2vos – MtFPGS + ADP
    
  • 2gc5, 2gc6, 2gcb – FPGS (mutant)
    
  • 1w78 – EcFPGS + ADP + DHPP – Escherichia coli
    
  • 1w7k – EcFPGS + ADP
    
  • 1jbv – LcFPGS + AMPPCP
    
  • 1jbw – LcFPGS + AMPPCP + folate derivative
    
  • 1fgs – LcFPGS + pyrophosphate