Uridylate kinase

Uridylate kinase (UK) catalyzes the reversible transfer of phosphate from UMP to UDP using ATP as a phosphate source. UDP is the starting point of synthesis of all other pyrimidine nucleotides. The eukaryotic UK has specificity to both UMP and CMP while the bacterial one is specific for UMP. The bacterial UK is Mg+2 dependent and is activated by GTP and repressed by UTP. The bacterial UK is composed of a C terminal ATP-binding domain and an N terminal UMP-binding domain.

3D structures of uridylate kinase3D structures of uridylate kinase

Updated on 17-December-2014

{"openlevels":0}

• Uridylate kinase
  • 1ybd – UK – Neisseria meningitides
    
  • 1z9d – UK – Streptococcus pyogenes
    
  • 2a1f - UK - Haemophilus influenza
    
  • 2brx – PfUK – Pyrococcus furiosus
    
  • 2ij9 – UK (mutant) – Archaeoglobus fulgidus
    
  • 2va1 - UK – Ureaplasma parvum
    
  • 3ek6 – XcUK – Xanthomonas campestris
• Uridylate kinase complex with nucleotides
  • 1ukz – yUK + AMP + ADP
    
  • 2bne – EcUK (mutant) + UMP – Escherichia coli
    
  • 2bnd - EcUK (mutant) + UDP
    
  • 2bnf - EcUK (mutant) + UTP
    
  • 2v4y - EcUK (mutant) + GTP
    
  • 2bmu - PfUK + UMP + AMPPNP
    
  • 2bri - PfUK + AMPPNP
    
  • 2ji5 - PfUK (mutant) + UTP
    
  • 2j4j - SsUK + UMP + AMPPCP – Sulfolobus solfataricus
    
  • 2j4k - SsUK + UMP
    
  • 2j4l - SsUK + UTP
    
  • 2jjx - UK + ATP + Mg – Bacillus anthracis
    
  • 1uky – yUK + ADP – yeast
    
  • 3ek5 - XcUK + GTP
    
  • 3nwy – UK + UTP + GTP – Mycobacterium tuberculosis
    
  • 4a7x, 4a7w - UK + UDP – Helicobacter pylori