Tubulin

FunctionFunction

Tubulin (TUB) is a constituent of microtubules in eukaryotes. Microtubules are assembled from dimers of α-tubulin (TUBA) and β-tubulin (TUBB) bound to GTP. See also Beta tubulin. γ-tubulin (TUBG) is part of the nucleation of microtubules. Human TUB contains several numbered subtypes. FtsZ (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB. See also Beta tubulin.

RelevanceRelevance

The chemotherapeutic drug Taxol interacts with TUBB. See Molecular Playground/Taxol.

3D Structures of Tubulin3D Structures of Tubulin

Updated on 15-February-2016

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• α-tubulin
  • 2bto – PdTUBA+thioredoxin 1 – Prosthecobacter dejongeii
    
  • 2e4h – hTUBA C terminal + restin CAP-Gly domain 2 – human
    
• α-tubulin + β-tubulin
  • 3hkb, 3hkc, 3hkd, 3hke, 3n2g, 3n2k, 3ryc, 3ryf, 3ryh, 3ryi – sTUBA+sTUBB+stathmin-4 – sheep
    
  • 4f61 - sTUBA+sTUBB+stathmin-like protein R4
    
  • 3ut5 - sTUBA+sTUBB+stathmin-4 + vinca peptide
    
  • 4eb6 - sTUBA+sTUBB+stathmin-4
    
  • 4drx - sTUBA+sTUBB + ankyrin repeat protein
    
  • 4lnu - sTUBA+sTUBB + ankyrin repeat protein + GDP + GTP + kinesin heavy chain
    
  • 4x1i, 4x1k, 4x1y, 4x20 - sTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + dolastatin + colchicine
    
  • 4f6r - sTUBA+sTUBB+stathmin-like protein R1 + ankyrin repeat protein
    
  • 2wbe – bTUBA1D+bTUBB2B+kinesin+AMPPNP – bovine
    
  • 3dco - bTUBA+bTUBB+kinesin-like NOD
    
  • 4ck5, 4ck6, 4ck7 - bTUBA+bTUBB+kinesin-like KIF11 motor domain
    
  • 1tvk - bTUBA+bTUBB+GDP+GTP+Epothilone A – electron crystallography
    
  • 3iz0 - bTUBA+bTUBB+hNDC80/SPC25+hNUF2/SPC24 – electron microscopy
    
  • 3edl - bTUBA1D+bTUBB2B+kinesin motor domain
    
  • 2xrp - bTUBA1D+bTUBB2B+doublecortin
    
  • 3du7, 3e22, 1z2b, 1sa0, 1sa1, 1ffx – bTUBA1C+bTUBB2B+stathmin-4
    
  • 4o2a, 4iij, 4i55 - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase
    
  • 4wbn - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative
    
  • 4o2b - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + colchicine
    
  • 4tuy, 4o4h, 4o4i, 4o4j, 4o4l, 4i50, 4i4t, 4tv8, 4tv9, 4yj2, 4yj3 - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + antimitotic agent
    
  • 1jff - bTUBA+bTUBB
    
  • 4hna - bTUBA+bTUBB + kinesin heavy chain + ankyrin repeat protein
    
  • 4uxo, 4uxp, 4uxr, 4uxs, 4uxy - bTUBA+bTUBB + kinesin motor domain + GDP + GTP + taxol – Cryo EM
    
  • 4uxt, 4uy0 - bTUBA+bTUBB + kinesin heavy chain + GDP + GTP + taxol – Cryo EM
    
  • 4ihj - bTUBA+bTUBB+stathmin-4 + tubulin tyrosine ligase + ADP
    
  • 3j1t, 3j1u - bTUBA+bTUBB+ dyenin
    
  • 3j2u - bTUBA+bTUBB+kinesin-like KLP10A head domain
    
  • 2p4n - hTUBA+hTUBB+kinesin heavy chain
    
  • 2hxf - pTUBA+pTUBB+kinesin-like KIF1A+AMPPNP – pig
    
  • 3j6f - pTUBA+pTUBB – Cryo EM
    
  • 3j6e - pTUBA+pTUBB +GMPCPP – Cryo EM
    
  • 3j7i - pTUBA+pTUBB +GTP – Cryo EM
    
  • 3j6g - pTUBA+pTUBB +GTP + GDP + taxol – Cryo EM
    
  • 3j6h - pTUBA+pTUBB +GMPCPP + kinesin heavy chain – Cryo EM
    
  • 3j8x - pTUBA+pTUBB +GDP + GTP + kinesin heavy chain – Cryo EM
    
  • 3j8y - pTUBA+pTUBB +GDP + GTP + ATP + kinesin heavy chain – Cryo EM
    
  • 3j6p - pTUBA+pTUBB +GTP + GDP + taxol + dynein heavy chain – Cryo EM
    
  • 2hxh - pTUBA+pTUBB+kinesin-like KIF1A+ADP
    
  • 1ia0 - pTUBA+pTUBB+kinesin-like KIF1A+ATP
    
  • 4abo - pTUBA+pTUBB+ microtubule integrity protein MAL3
    
  • 1tub - pTUBA+pTUBB – electron diffraction
    
  • 4aqv, 4aqw - bTUBA+bTUBB+kinesin-like KIF11 – Cryo EM
    
  • 4atu - bTUBA1D+bTUBB2B+doublecortin – Cryo EM
    
  • 4atx - bTUBA1D+bTUBB2B+kinesin motor domain – Cryo EM
    
  • 2btq – PdTUBA+PdTUBB
    
  • 4ffb, 4u3j - TUBA+TUBB (mutant) + protein STU2 - yeast
• γ-tubulin
  • 3cb2 – hTUBG1+GDP
    
  • 1z5v - hTUBG1+GTPgS
    
  • 1z5w - hTUBG1+GTP
    
  • 3rip – hTUBG4
    
• FtsZ
  • 2vxy, 2vam – BsFtsZ - Bacillus subtilis
    
  • 2ve8 – PaFtsZ gamma domain – Pseudomonas aeruginosa
    
  • 2r6r– AaFtsZ - Aquifex aeolicus
    
  • 1w59, 1fsz – MjFtsZ - Methancaldococcus jannaschii
    
  • 1w5e, 1w5f – MjFtsZ (mutant)
    
  • 3v3t – FtsZ (mutant) – Clostridium botulinum
    
  • 3zid – FtsZ – Methanosaeta thermophila
    
  • 3vo9, 3vpa - SaFtsZ – Staphylococcus aureus
    
  • 3wgj, 3wgk – SaFtsZ (mutant)
    
• FtsZ complexes
  • 2rhh, 2rhj – BsFtsZ+SO4
    
  • 2rhl - BsFtsZ+GDP
    
  • 2rho - BsFtsZ+GDP+GTP-gamma-S
    
  • 4u39 – BsFtsZ + cell division factor
    
  • 2ve9 - PaFtsZ gamma domain+DNA
    
  • 2vaw – PaFtsZ+GDP
    
  • 1ofu - PaFtsZ+SULA
    
  • 2r75 - AaFtsZ+8-morpholino-GTP
    
  • 2q1x, 1rq2 - MtFtsZ+citrate – Mycobacterium tuberculosis
    
  • 2q1y, 1rlu - MtFtsZ+GTP-gamma-S
    
  • 1rq7, 4kwe - MtFtsZ+GDP
    
  • 2vap – MjFtsZ+GDP
    
  • 1w58 - MjFtsZ+GMPCPP
    
  • 1w5a - MjFtsZ+MgGTP
    
  • 1w5b - MjFtsZ+GTP
    
  • 4b45 – HvFtsZ + GTP-γS – Haloferax volcanii
    
  • 3vo8, 3voa - SaFtsZ + GDP
    
  • 3wgl – SaFtsZ (mutant) + GDP
    
  • 3wgn – SaFtsZ + GTP-γS
    
  • 3wgm – SaFtsZ (mutant) + GTP
    
  • 3vob - SaFtsZ + GDP + benzamide derivative
    
  • 4dxd - SaFtsZ + antibiotic
    
  • 4b46 - HvFtsZ + GDP
    
  • 4m8i - SeFtsZ + GDP – Staphylococcus epidermitis