Phosphoglycerate dehydrogenase

spinqualitylabelsall models Human phosphoglycerate dehydrogenase dimer complex with malate and cofactor NAD 2g76 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

FunctionFunction

Phosphoglycerate dehydrogenase (PGDH) catalyzes the conversion of 3-phosphoglycerate into 3-phosphohydroxypyruvate. This is the first step of serine biosynthesis. NAD is used as cofactor. In some cancer cells there is an elevation in PGDH level.

Structural highlightsStructural highlights

See Rossmann fold.

3D structures of phosphoglycerate dehydrogenase3D structures of phosphoglycerate dehydrogenase

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• Phosphoglycerate dehydrogenase
  • 1ygy, 3dc2 – MtPGDH – Mycobacterium tuberculosis
    
  • 3evt - PGDH – Lactobacillus plantarum
    
  • 3gg9 - PGDH – Ralstonia solanacearum
    
  • 3k5p - PGDH (mutant) – Brucella melitensis
• Phosphoglycerate dehydrogenase binary complex
  • 1sc6, 2p9c, 2p9e, 2p9g - EcPGDH (mutant) + NAD – Escherichia coli
    
  • 1yba - EcPGDH + NAD
    
  • 1wwk - PGDH + NAD – Pyrococcus horikoshii
    
  • 2g76 - PGDH + NAD – human
    
  • 2ekl - PGDH + NAD – Sulfolobus tokodaii
    
  • 3ddn - MtPGDH + hydroxypyruvic acid phosphate
• Phosphoglycerate dehydrogenase ternary complex
  • 1psd - EcPGDH + serine + NAD
    
  • 2pa3 - EcPGDH (mutant) + serine + NAD