Bromodomain-containing protein

Function Bromodomain-containing proteins (BRD) are active as histone acetyltransferase, chromatin remodeling and transcriptional mediation. The bromodomain is a ca. 110 amino acid long sequence which recognizes acetylated lysine residues which are found in the C-terminal of histones. to the rescue. For detalis on BRD3 see Human bromodomain containing protein 3 Disease Dysfunction of BRD is involved in cancer, inflammation and multiple sclerosis. Structural highlights This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

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3D Structures of bromodomain-containing protein3D Structures of bromodomain-containing protein

Updated on 10-February-2016

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• Bromodomain-containing protein 1
  • 3lyi – hBRD1 PWWP domain - human
    
  • 2ku3 – hBRD1 PHD1 zinc finger domain - NMR
    
  • 2lq6 – hBRD1 PHD2 zinc finger domain (mutant) - NMR
    
  • 3l43 – histone H3.3 N-terminal/hBRD1 PHD1 zinc finger domain - NMR
    
  • 3rcw – hBRD1 bromodomain
    
  • 5ame – hBRD1 bromodomain+PHD (mutant) + piperazine derivative
    
  • 5amf – hBRD1 bromodomain+PHD (mutant) + indazole derivative
    
  • 5fg6 – hBRD1 bromodomain+PHD + probe
    
  • 4z02 – hBRD1 residues 925-1049 + quinoline derivative
    
• Bromodomain-containing protein 2
  • 1x0j, 2dvv – hBRD2 N-terminal bromodomain
    
  • 5hel, 5hem, 5hen, 5hfq – hBRD2 N-terminal bromodomain (mutant)
    
  • 2g4a – hBRD2 residues 1-116 - NMR
    
  • 4qeu, 5dfb – hBRD2 bromodomain 2 (mutant)
    
• Bromodomain-containing protein 2 complex
  • 2dvq, 2dvr, 2dvs, 2e3k – hBRD2 N-terminal bromodomain + histone H4 peptide
    
  • 3oni – hBRD2 residues 224-335 + inhibitor
    
  • 3aqa, 2ydw, 2yek, 4a9e, 4a9f, 4a9h, 4a9i, 4a9j, 4a9m, 4a9n, 4a9o, 4alh, 4akn, 4alg, 4uyf, 4uyg, 4uyh – hBRD2 N-terminal bromodomain + inhibitor
    
  • 4mr5, 4mr6, 4j1p – hBRD2 bromodomain 2 + inhibitor
    
  • 5bt5 – hBRD2 bromodomain 2 + probe
    
  • 4qev, 4qew – hBRD2 bromodomain 2 (mutant) + probe
    
  • 5dfc, 5dfd – hBRD2 bromodomain 2 (mutant) + ligand
    
• Bromodomain-containing protein 3
  • 2nxb – hBRD3 bromodomain 1
    
  • 2yw5 – hBRD3 bromodomain 1 - NMR
    
  • 3s91, 3s92 – hBRD3 bromodomain 1 + inhibitor
    
  • 2l5e – mBRD3 bromodomain 1 + GATA-1 C-terminal – mouse - NMR
    
  • 2oo1 – hBRD3 bromodomain 2
    
  • 2e7n – hBRD3 bromodomain 2 - NMR
    
  • 5hfr – hBRD3 bromodomain 2 (mutant)
    
• Bromodomain-containing protein 4
  • 2oss, 4j3i, 4lyi – hBRD4 bromodomain 1
    
  • 2ouo – hBRD4 bromodomain 2
    
  • 2i8n – hBRD4 bromodomain 2 - NMR
    
  • 3jvj – mBRD4 bromodomain 1
    
  • 2dww, 3jvl, 3jvm – mBRD4 bromodomain 2
    
  • 2jns – mBRD4 ET domain - NMR
    
• Bromodomain-containing protein 4 bromodomain 1 complex
  • 3jvk, 3muk, 3mul – mBRD4 bromodomain 1 + histone H3.3 peptide
    
  • 3uvw, 3uvy, 3uvx, 3uw9 – hBRD4 bromodomain 1 + histone H4 peptide
    
  • 4kv1 – hBRD4 bromodomain 1 + Rel peptide
    
  • 3mxf – mBRD4 bromodomain 1 + inhibitor
    
  • 3p5o, 2yel, 3zyu, 3u5j, 3u5k, 4a9l, 4e96, 4f3i, 4hxk, 4hxl, 4hxm, 4hxn, 4hxo, 4hxp, 4hxr, 4hxs, 4lr6, 4lrg, 3svf, 3svg, 4gpj, 4hbv, 4hbw, 4hbx, 4hby, 4don, 4j0r, 4j0s, 4bw1, 4bw2, 4bw3, 4bw4, 4men, 4meo, 4mep, 4meq, 4bjx, 4c66, 4c67, 4ioo, 4ioq, 4ior, 4mr3, 4mr4, 4nqm, 4nr8, 4cfk, 4cfl, 4lyw, 4ogi, 4ogj, 4o70, 4o71, 4o72, 4o74, 4o75, 4o76, 4o77, 4o78, 4o7a, 4o7b, 4o7c, 4o7e, 4o7f, 4ps5, 4nuc, 4nue, 4nud, 4pce, 4pci, 4uyd, 4qzs, 4wiv, 4cl9, 4clb, 4xy9, 4xya, 4z1q, 4z1s, 4uix, 4uiy, 4uiz, 4qr3, 4qr4, 4qr5, 5bt4, 5a5s, 5a85, 5acy, 4x2i, 4zc9, 5fbx, 4yh3, 4yh4, 5coi, 5cp5, 5cpe, 5cqt, 5crm, 5crz, 5cs8, 5ctl, 5cy9, 5d0c, 5dx4, 4lzs, 5d24, 5d25, 5d26, 5d3h, 5d3j, 5d3l, 5d3n, 5d3p, 5d3r, 5d3s, 5d3t, 5egu, 5ei4, 5eis, 5hls, 5hm0 – hBRD4 bromodomain 1 + inhibitor
    
  • 4lys, 4lzr – hBRD4 bromodomain 1 + colchiceine
    
  • 4qb3 – hBRD4 bromodomain 1 + olinone
    
  • 4whw – hBRD4 bromodomain 1 + probe
    
• Bromodomain-containing protein 4 bromodomain 2 complex
  • 2yem, 4z93 – hBRD4 bromodomain 2 + inhibitor
    
  • 2lsp – hBRD4 bromodomain 2 + Nf-Kb peptide
    
  • 4kv4 – hBRD4 bromodomain 2 + Rel peptide
    
  • 2mjv – hBRD4 bromodomain 2 + Twist peptide
    
• Bromodomain-containing protein 9
  • 3hme – hBRD9 bromodomain
    
  • 4nqn, 4xy8, 4z6h, 4z6i, 5e9v – hBRD9 bromodomain + inhibitor
    
  • 4yy4 – hBRD9 bromodomain + DMSO
    
  • 4yy6, 4yyd, 4yyg, 4yyh, 4yyj, 4yyk – hBRD9 bromodomain + histone H4 peptide
    
  • 4uit, 4uiu, 4uiv, 4uiw – hBRD9 N-terminal bromodomain + inhibitor