3e7v
Crystal Structure of Human Haspin with a pyrazolo-pyrimidine ligandCrystal Structure of Human Haspin with a pyrazolo-pyrimidine ligand
Structural highlights
Function[HASP_HUMAN] Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.[1] [2] [3] [4] [5] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See AlsoReferences
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Homo sapiens
- Non-specific serine/threonine protein kinase
- Arrowsmith, C H
- Bountra, C
- Burgess-Brown, N
- Delft, F Von
- Edwards, A M
- Eswaran, J
- Fedorov, O
- Filippakopoulos, P
- Keates, T
- Knapp, S
- Pike, A C.W
- Structural genomic
- Wickstroem, M
- Atp-binding
- Cell cycle
- Chromatin regulator
- Haploid germ cell specific nuclear protein kinase
- Haspin
- Kinase
- Magnesium
- Nucleotide-binding
- Nucleus
- Phosphoprotein
- Serine/threonine-protein kinase
- Sgc
- Transferase