Estrogen-related receptor

Function Estrogen-related receptor (ERR) binds to estrogen response elements on DNA and modulates transcription in response to hormone. There are 3 classes of ERR : ERRα, ERRβ and ERRγ. Relevance ERR plays a role in energy homeostasis and cancer.

spinqualitylabelsall models Human estrogen-related receptor γ ligand-binding domain (cyan, grey, green, yellow, pink, purple) complex with nuclear receptor corepressor 2 peptide (dark red, orange) and 4-hydroxytamoxifen (PDB code 2gpv) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of estrogen-related receptor3D structures of estrogen-related receptor

Updated on 20-January-2016

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• ERR
  • 1xb7, 3d24 – hERR ligand-binding domain + peroxisome proliferator activated receptor coactivator 1 peptide – human
    2pjl - hERR ligand-binding domain (mutant) + inverse agonist
    
  • 3k6p - hERR ligand-binding domain + ligand
• ERRβ
  • 1lo1 – hERR DNA-binding domain + DNA - NMR
• ERRγ
  • 2gp7, 2zbs - hERR ligand-binding domain
    
  • 1kv6, 1tfc – hERR ligand-binding domain + steroid receptor coactivator 1 2nd NR-Box
    
  • 2gpo, 2gpp - hERR ligand-binding domain + nuclear receptor-interacting protein 1 peptide
    
  • 2ewp - hERR ligand-binding domain + tamoxifen analog
    
  • 2gpu, 2p7z - hERR ligand-binding domain + 4-hydroxytamoxifen
    
  • 2e2r, 2p7g - hERR ligand-binding domain + bisphenol A
    
  • 2zkc - hERR ligand-binding domain + bisphenol Z
    
  • 2zas - hERR ligand-binding domain + bisphenol A derivative
    
  • 2p7a - hERR ligand-binding domain + methyl phenol
    
  • 2gpv - hERR ligand-binding domain + nuclear receptor corepressor 2 peptide + 4-hydroxytamoxifen
    
  • 1s9p, 1s9q - mERR ligand-binding domain + diethylstilbesterol – mouse
    
  • 1vjb - mERR ligand-binding domain + 4-hydroxytamoxifen