1waq
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CRYSTAL STRUCTURE OF HUMAN GROWTH AND DIFFERENTIATION FACTOR 5 (GDF-5)
OverviewOverview
Growth and differentiation factor 5 (GDF-5), a member of the TGF-beta, superfamily, is involved in many developmental processes, like, chondrogenesis and joint formation. Mutations in GDF-5 lead to diseases, e.g. chondrodysplasias like Hunter-Thompson, Grebe and DuPan syndromes and, brachydactyly. Similar to other TGF-beta superfamily members, GDF-5, transmits signals through binding to two different types of membrane-bound, serine-/threonine-kinase receptors termed type I and type II. In contrast, to the large number of ligands, only seven type I and five type II, receptors have been identified to date, implicating a limited promiscuity, in ligand-receptor interaction. However, in contrast to other members of, the TGF-beta superfamily, GDF-5 shows a pronounced specificity in type I, ... [(full description)]
About this StructureAbout this Structure
1WAQ is a [Single protein] structure of sequence from [Homo sapiens] with MPD as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
A single residue of GDF-5 defines binding specificity to BMP receptor IB., Nickel J, Kotzsch A, Sebald W, Mueller TD, J Mol Biol. 2005 Jun 24;349(5):933-47. Epub 2005 Apr 22. PMID:15890363
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