Stathmin

Stathmin (STM) regulates microtubules dynamics. Microtubules undergo continuous assembly and disassembly in the cell’s cytoskeleton. STM binds to tubulin and prevents the latter from polymerization thus preventing microtubule assembly. Phosphorylation of STM weakens the binding of STM to tubulin enabling the microtubule assembly needed for the formation of mitotic spindle. Thus, STM is an oncoprotein. STM contains an SLD (stathmin-Like Domain) domain of 149 residues which binds the tubulin dimer.

spinqualitylabelsall models Rat stathmin SLD domain (magenta) complex with tubulin α chain (grey, pink), tubulin β chain (green, yellow), GTP, sulfate and Mg+2 ions (PDB code 3ryf) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of stathmin3D Structures of stathmin

Updated on 20-July-2015

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• Stathmin SLD domain complex with tubulin
  • 3ryf – rSTM + tubulin + GTP - rat
    
  • 3hkb, 3ryc, 3ryi – rSTM + tubulin + GTP + GDP
    
  • 3ryh – rSTM + tubulin + GTP + phosphomethylphosphonic acid guanylate
    
  • 3hkc, 3n2g, 3n2k – rSTM + tubulin + GTP + GDP + pyridine derivative
    
  • 3hkd – rSTM + tubulin + GTP + GDP + pyrrolidine derivative
    
  • 3hke – rSTM + tubulin + GTP + GDP + benzenesulfonamide derivative
    
• Stathmin SLD domain complex with tubulin and drugs
  • 1sa0 – rSTM + tubulin + GTP + GDP + anti-gout drug
    
  • 1sa1, 1z2b – rSTM + tubulin + GTP + GDP + anti-wart drug
    
  • 4eb6 – rSTM (mutant) + tubulin + GTP + GDP + anti-cancer drug
    
  • 3du7 – rSTM + tubulin + GTP + GDP + phomopsine + colchicine
    
  • 3e22 – rSTM + tubulin + GTP + GDP + soblidotine + colchicine
    
  • 3ut5 – rSTM (mutant) + tubulin + GTP + GDP + ustiloxine + colchicine + Vinca tetrapeptide
    
• Stathmin SLD domain complex with tubulin and tubulin tyrosine ligase
  • 4iij – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP
    
  • 4ihj – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP
    
  • 4wbn – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + phosphomethylphosphonic acid adenylate
    
  • 4o2a – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP + inhibitor
    
  • 4i4t – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + zampanolide
    
  • 4i50 – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + epothilone
    
  • 4o4l, 4tuy, 4tv8, 4yj2, 4yj3 – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + anti-cancer drugs
    
  • 4i55 – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + phosphomethylphosphonic acid adenylate
    
  • 4o2b – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + phosphomethylphosphonic acid adenylate + anti-gout drug
    
  • 4o4h, 4o4j, 4o4i – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + phosphomethylphosphonic acid adenylate + anti-cancer drug