4c16

E-selectin lectin, EGF-like and two SCR domains complexed with glycomimetic antagonistE-selectin lectin, EGF-like and two SCR domains complexed with glycomimetic antagonist

Structural highlights

4c16 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , , , ,
Related:	4c17
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[LYAM2_HUMAN] Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.^[1]

References

↑ Hession C, Osborn L, Goff D, Chi-Rosso G, Vassallo C, Pasek M, Pittack C, Tizard R, Goelz S, McCarthy K, et al.. Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions. Proc Natl Acad Sci U S A. 1990 Mar;87(5):1673-7. PMID:1689848

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OCA

[1] Hession C, Osborn L, Goff D, Chi-Rosso G, Vassallo C, Pasek M, Pittack C, Tizard R, Goelz S, McCarthy K, et al.. Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions. Proc Natl Acad Sci U S A. 1990 Mar;87(5):1673-7. PMID:1689848

[1]

4c16

E-selectin lectin, EGF-like and two SCR domains complexed with glycomimetic antagonistE-selectin lectin, EGF-like and two SCR domains complexed with glycomimetic antagonist

Structural highlights

Function

References

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4c16

E-selectin lectin, EGF-like and two SCR domains complexed with glycomimetic antagonistE-selectin lectin, EGF-like and two SCR domains complexed with glycomimetic antagonist

Structural highlights

Function

References

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