4yub

Crystal structure of human Nicotinic Acid PhosphoribosyltransferaseCrystal structure of human Nicotinic Acid Phosphoribosyltransferase

Structural highlights

4yub is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Activity:	Nicotinate phosphoribosyltransferase, with EC number 6.3.4.21
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[PNCB_HUMAN] Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells.^[1] Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.

References

↑ Hara N, Yamada K, Shibata T, Osago H, Hashimoto T, Tsuchiya M. Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells. J Biol Chem. 2007 Aug 24;282(34):24574-82. Epub 2007 Jun 29. PMID:17604275 doi:http://dx.doi.org/10.1074/jbc.M610357200

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OCA

[1] Hara N, Yamada K, Shibata T, Osago H, Hashimoto T, Tsuchiya M. Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells. J Biol Chem. 2007 Aug 24;282(34):24574-82. Epub 2007 Jun 29. PMID:17604275 doi:http://dx.doi.org/10.1074/jbc.M610357200

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