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4jef

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Crystal structure of human thymidylate synthase Y202A in inactive conformation.Crystal structure of human thymidylate synthase Y202A in inactive conformation.

Structural highlights

4jef is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
NonStd Res:
Activity:Thymidylate synthase, with EC number 2.1.1.45
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.[1]

References

  1. ↑ Anderson DD, Quintero CM, Stover PJ. Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15163-8. doi:, 10.1073/pnas.1103623108. Epub 2011 Aug 26. PMID:21876188 doi:10.1073/pnas.1103623108

4jef, resolution 2.31Å

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