3wpe

Crystal structure of bovine TLR9 in complex with agonistic DNA1668_12merCrystal structure of bovine TLR9 in complex with agonistic DNA1668_12mer

Structural highlights 3wpe is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 3wpb, 3wpc, 3wpd, 3wpf, 3wpg, 3wph, 3wpi Resources: FirstGlance, OCA, RCSB, PDBsum Function [TLR9_BOVIN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

spinqualitylabelsall models 3wpe, resolution 2.38Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image