4x0q

Ternary complex of human DNA polymerase theta C-terminal domain binding ddGTP opposite dCMPTernary complex of human DNA polymerase theta C-terminal domain binding ddGTP opposite dCMP

Structural highlights

4x0q is a 6 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Related:	4x0p
Activity:	DNA-directed DNA polymerase, with EC number 2.7.7.7
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[DPOLQ_HUMAN] Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links.^[1]

References

↑ Seki M, Marini F, Wood RD. POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells. Nucleic Acids Res. 2003 Nov 1;31(21):6117-26. PMID:14576298

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OCA

[1] Seki M, Marini F, Wood RD. POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells. Nucleic Acids Res. 2003 Nov 1;31(21):6117-26. PMID:14576298

[1]

4x0q

Ternary complex of human DNA polymerase theta C-terminal domain binding ddGTP opposite dCMPTernary complex of human DNA polymerase theta C-terminal domain binding ddGTP opposite dCMP

Structural highlights

Function

References

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4x0q

Ternary complex of human DNA polymerase theta C-terminal domain binding ddGTP opposite dCMPTernary complex of human DNA polymerase theta C-terminal domain binding ddGTP opposite dCMP

Structural highlights

Function

References

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