Eukaryotic initiation factor

Eukaryotic initiation factors (EIF) are involved in the initiation of protein translation. They form a complex with the small subunit of the ribosome and Met-tRNA which scans the mRNA and recognizes the initiation codon AUG. For details on EIF4 see C-terminal portion of human eIF4GI.

3D structures of eukaryotic initiation factor3D structures of eukaryotic initiation factor

Updated on 24-November-2014

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• EIF1
  • 2if1, 1d7q – hEIF1 – human – NMR
    
  • 2ogh - yEIF1 – NMR
    
• EIF2
  • 1kl9 – hEIF2A
    
  • 1q8x – hEIF2A - NMR
    
  • 1si2, 1si3, 4ei3, 4f3t – hEIF2C PAZ domain + DNA
    
  • 3luk - hEIF2C MID domain
    
  • 3lud, 3lug, 3luh, 3luj, 3qx8, 3qx9 - hEIF2C MID domain + nucleotide
    
  • 1q46 – yEIF2A – yeast
    
  • 2a19, 2a1a – yEIF2A (mutant) + interferon-induced protein kinase
    
  • 3ecs – hEIF2B
• EIF3
  • 2nlw - hEIF3B RNA recognition domain – NMR
    
  • 3ns5, 3ns6 - yEIF3B RNA recognition domain
    
  • 2krb - hEIF3B RNA recognition domain + hEIF3J peptide
    
  • 2cq0 – hEIF3G RNA recognition domain – NMR
    
  • 3zwl - yEIF3I + EIF3B C terminal
    
  • 3bpj – hEIF3J
    
  • 1rz4 – hEIF3K
• EIF4
  • 1fuk – yEIF4A C terminal
    
  • 1fuu - yEIF4A mRNA helicase domain
    
  • 2g9n, 3bor – hEIF4A DEAD domain
    
  • 3ex7, 2xb2 – hEIF4A + MAGO homolog + RNA-binding protein 8A + CASC3 + RNA
    
  • 2zu6, 3eiq – hEIF4A + programmed cell death protein
    
  • 1wi8, 2j76 – hEIF4B RNA recognition domain - NMR
    
  • 1ejh – mEIF4E + EIF4G peptide + GDP – mouse
    
  • 1ej1, 1l8b - mEIF4E + nucleotide
    
  • 2gpq, 3tf2 – hEIF4E
    
  • 2wmc - EIF4E - pea
    
  • 2idr – wEIF4E – wheat
    
  • 2idv - wEIF4E (mutant) + GDP
    
  • 1ipb, 1ipc - hEIF4E + nucleotide
    
  • 4dt6, 4dum – hEIF4E + inhibitor
    
  • 2w97 – hEIF4E + hEIF4G peptide
    
  • 1wkw - hEIF4E + EIF4E-binding protein peptide + GDP
    
  • 2v8w, 2v8x, 2v8y, 3u7x - hEIF4E + EIF4E-binding protein peptide
    
  • 3am7 - hEIF4E + EIF4E-binding protein peptide + nucleotide
    
  • 1ej4 - mEIF4E + EIF4E-binding protein peptide
    
  • 3hxg, 3hxi - EIF4E + EIF4E-binding protein peptide + GDP – Schistosoma mansoni
    
  • 3m93, 3m94 - EIF4E + EIF4E-binding protein peptide + nucleotide – Pig roundworm
    
  • 1ap8 – yEIF4E + GDP – NMR
    
  • 1rf8 - yEIF4E + yEIF4GI peptide + GDP
    
  • 2vso, 2vsx - yEIF4E + yEIF4F
    
  • 3l6a - hEIF4GII C terminal
    
  • 1ug3 – hEIF4GI C terminal (mutant)
    
  • 1hu3, 3d3m – hEIF4GII middle domain
    
  • 2dng – hEIF4H RNA recognition domain – NMR
    
• EIF5
  • 1eif, 2eif – EIF5A – Methanocaldococcus janaschii
    
  • 1x6o – EIF5A – Leishmania braziliensis
    
  • 1xtd - EIF5A – Leishmania mexicana
    
  • 3hks – EIF5A – Arabidopsis thaliana
    
  • 3cpf - hEIF
    
  • 2ful – yEIF5 C terminal
    
  • 2iu1 - hEIF5 C terminal
    
  • 2g2k – hEIF5 N terminal (mutant) – NMR
    
  • 2e9h – hEIF5 – NMR
    
  • 3cpf – hEIF5A
    
  • 3er0 - yEIF5A
    
• EIF6
  • 1g62 – yEIF6
    
  • 2x7n – yEIF6S + sarcin-ricin loop + ribosomal protein L23 + ribosomal protein L24